News
Investigator meeting
2021-05-15The first National Investigator Meeting of ENCHANTED-MT (ENCHANTED2) study, co-organised by the George Institute for Global Health (China) and the First Affiliated Hospital of the Naval Medical University (Shanghai Changhai Hospital), was successfully held in Beijing recently.
ENCHANTED-MT builds upon the findings of the Enhanced Control of Hypertension and Thrombectomy Stroke Study (ENCHANTED) - which demonstrated the effects of low-dose thrombolysis treatment with rtPA, and of early intensive blood pressure lowering in patients with acute ischaemic stroke who were eligible for reperfusion therapy in the fist few hours after the onset of symptoms. ENCHANTED-MT aims to further determine the most appropriate level of blood pressure control in patients who receive mechanical thrombectomy for the most severe type of acute ischemic stroke, that caused by an occlusion of a large blood vessel to the brain.
This study is the first large clinical trial to address this important clinical and research question on patient-centred outcomes, to provide the highest-level of evidence for guideline and policy recommendations. The findings of a multicentre French study were published in early 2021 showing that intensive blood pressure lowering did not affect bleeding in the brain but it did not include a sufficiently large number of patients to reliably determine whether the treatment improve recovery after stroke.
In addition, as this study is jointly implemented by the ENCHANTED team of the George Institute for Global Health (China) and the DIRECT-MT team of Shanghai Changhai Hospital, the abbreviated name of the project, ENCHANTED-MT was released through the new logo launch event during the meeting.
2021-06-18
Shortly after the first Investigators Meeting, ENCHANTED-MT held another communication meeting, inviting more than 80 investigators across China. At the meeting, training on blood pressure control and endpoint event assessment was reinforced, experiences in high-quality clinical research were shared, and specific requirements for project quality management were put forward. Experts from various fields, including statistics and clinical trials, as well as experienced lead investigators were invited to introduce a comprehensive overview of clinical research from different academic perspectives.